About the Zarif Lab
Research Overview:
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Tumor-Associated Immune Cells: Investigating how immune cells traffic to the tumor microenvironment and promote tumor growth, therapeutic resistance, and metastasis.
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Metabolic Targets & Biomarkers: Identifying novel biomarkers and metabolic dependencies that may be exploited as therapeutic targets in metastatic prostate cancer.
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M2 Tumor-Associated Macrophages (M2-TAMs): Characterizing M2-TAM infiltration in metastatic castration-resistant prostate cancer (mCRPC) using samples from the Johns Hopkins Rapid Autopsy Program.
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Macrophages in the Tumor Microenvironment: Studying the abundance and distribution of M2-TAMs and inflammatory macrophages across patient tumor samples.
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Bone Metastasis: Investigating M2-TAM infiltration in mCRPC that has metastasized to bone and its potential role in the metastatic tumor microenvironment.
People
The Zarif Lab is home to post-docs, PhD students, staff, and other collaborators from different fields who research immunology and tumor biology expertise to study prostate cancer.
Research
Learn about how the Zarif Lab studies immune cells in the tumor microenvironment drive prostate cancer progression, treatment resistance, and metastasis. Our research focuses on identifying therapeutic targets, with an emphasis on M2 tumor-associated macrophages and metastatic prostate cancer.
Publications
Learn more about the Zarif Lab’s most recent discoveries in past and recent peer-reviewed publications and scholarly journal articles.
News
Find more information about our center areas, ongoing research, software, data, protocols and methods and other recent news.